In all studies, Aldara was compared with placebo (the same cream but without the active substance). Aldara has been studied in 923 patients with genital warts in four main studies lasting 16 weeks. generic aldara 5% cream online The main measure of effectiveness was the number of patients with total clearance of treated warts. Aldara has also been studied in 724 patients with small basal-cell carcinomas in two studies where patients were treated for six weeks, and used Aldara or placebo either five times a week or every day. The main measure of effectiveness was the number of patients with total clearance of the tumours after 12 weeks. Aldara has also been studied in patients with actinic keratoses in two studies involving a total of 505 patients. The main measure of effectiveness was the number of patients whose keratoses had cleared after one or two four-week courses of treatment. Do's and don'ts: Before each application, wash your hands and the area of skin you are going to treat with mild soap and water and dry thoroughly. Wash your hands again after applying the cream. Don't apply the cream to broken, inflamed or normal healthy skin and take care to avoid getting it in contact with your eyes, lips and nostrils. Don't cover the treated area with dressings or bandages. After you've applied the cream, don't shower or bathe until it's time to wash the cream off (see below). DO remember to remove the cream with mild soap and water after the treatment time is up. Applying an excessive amount of cream, or leaving it on too long can cause a severe skin reaction. If you forget to apply the cream before going to bed, just leave out that dose and apply your next dose the following bedtime. Don't apply the cream twice in one day to make up for a forgotten application. If you get a severe skin reaction that causes you discomfort, do remove the cream by washing the area with mild soap and water. On rare occasions, skin reactions may be accompanied by flu-like symptoms such as fever, nausea or aches and pains. If necessary, you can take a rest period of several days before starting treatment again. If you get an infection at the application site do see your doctor so it can be treated. If necessary, you can take a rest period of several days before starting the treatment again.
Before applying Aldara, the patient should wash the treatment area with mild soap and water and allow the area to dry thoroughly. Aldara is to be applied to the affected area prior to normal sleeping hours and should be left on the skin for approximately 8 hours (6-10 hours). The cream should be rubbed in until it is no longer visible. Following the treatment period, the cream should be removed by washing the treated area with mild soap and water. During the 6-10 hours treatment period showering or bathing should be avoided. Hand washing before and after cream application is recommended. Local skin reactions (erythema) at the treatment area are common. These reactions may be due to the pharmacological response of the body's immune system to Aldara. In clinical studies in patients with sBCC the histological clearance following Aldara therapy was statistically (p 2 . The recommended dose per application is 4 actuations or one sachet. Treatment should be initiated and monitored by a physician using either of the following two dosage regimens.
Advise patients to adhere to the treatment schedule and not to apply excess cream to the treatment area
Treatment schedules for imiquimod reflect a balance between achieving therapeutic efficacy with tolerability of LSRs. http://www.webmd.com/drugs/2/drug-1191-8193/imiquimod-topical/imiquimod-topical/details A treatment regimen of 5 days/week is recommended for sBCC because of the improved safety profile and similar clearance rates with this dose compared with daily treatment,19 while for SK the recommended treatment schedule is three times per week.2 Higher than recommended doses may lead to increased LSRs. The contents of one 250 mg sachet or the amount delivered in one full actuation of the pump may be more than is required for a single application. Advise patients against applying excessive cream to the treatment area and to discard unused cream at each application. In the event of a severe LSR, the cream should be removed by washing the treatment area with mild soap and water. Interruptions in treatment are recommended to allow severe inflammatory reactions to resolve.2 In clinical studies there were few discontinuations due to LSRs, and rest periods were taken around 3–4 weeks after treatment started but occurred as early as the first and as late as the last week of treatment.